Cabozantinib Cas 849217-68-1

Cabozantinib Cas 849217-68-1
99% Purity Pharmaceutical Raw Materials Cabozantinib CAS 849217-68-1 API Powder Cabozantinib Malate XL184 In Stock with High Quality and Good Price for Sale Products Specifications: 99% Cabozantinib powder Product Description Product name: Cabozantinib CAS: 849217-68-1 Product Name: Supply...
Product Details

99% Purity Pharmaceutical Raw Materials Cabozantinib CAS 849217-68-1 API Powder Cabozantinib Malate XL184 In Stock with High Quality and Good Price for Sale

Products Specifications:
 99% Cabozantinib powder 

Product Description
 Product name: Cabozantinib
 CAS: 849217-68-1
 Product Name:   Supply cabozantinib/ XL184 CAS:849217-68-1
 Specification:    99% 
 Testing Method: HPLC
 Appearance:  white fine powder
 
 Cabozantinib Introduction:
 Cabozantinib (marketed under the tradename Cometriq, formerly known as XL184) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM. XL-184 also displays potent activity against Met, Ret, Kit, FLT1, FLT3, FLT4, Tie2, and AXL. XL184 at low concentration(0.1-0.5 μM) is sufficient to induce marked inhibition of constitutive and inducible Met phosphorylation and its resultant downstream signaling in MPNST cells, and inhibit HGF-induced MPNST cell migration and invasion.
 
 Specification

Tests

Specifications

Results

Characters

White to off-white crystalline powder with a characteristic sulfide-like order

Complies

Identification

IR:similar to Reference Standard

Complies

Appearance of solution

Clear and colorless

Complies

Specific Rotation

-127°to -132°

-131°

Loss on Drying

≤0.5%

0.06%

Sulphated Ash

≤0.2%

0.03%

Heavy metals

≤0.002%

Complies

pH

2.0 to 2.6

2.3

Related Compouds

1. 1.    Single Impurity ≤1.0%
     2. 2.    Sum of Impurity≤2.0%

Undetected
     Undetected

Assay(Anhydrous)

98.0% to 101.5%

100.2%


Function
 Cabozantinib (sold under the trade name Cometriq, formerly known as XL184) is an effective VEGFR2 inhibitor with an IC50 of 0.035 nM. XL-184 also shows effective activity against Met, Ret, Kit, FLT1, FLT3, FLT4, Tie2 and AXL. Low concentrations (0.1-0.5 [mu] M) of XL184 were sufficient to induce significant inhibition of histological and inducible Met phosphorylation and its downstream signaling in MPNST cells and inhibit HGF-induced migration and invasion of MPNST cellsn

The quality control process
 1) Purchasing
 Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
 2) Inspection
 Four steps: sampling, sample pretreatment, measuring and data processing.
 3) Producing
 a) Each operator must do self-inspection of producs and make the corresponding inspection records.
 b) Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
 4) Before selling
 Test result can be provided before selling.
 Third-party detection institution is allowed if you are not satisfied with test results.
 
 OUR ADWANTAGE:
 High quality with competitive price:
 1) Standard: Enterprise Standard
 2) All Purity≥99%
 3) We are manufacturer and can provide high quality products with factory price.
 
 We have clients throughout the world.
 1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
 2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
 3) High quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers.


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