Cabozantinib Powder For Cancer Treatment

Cabozantinib Powder For Cancer Treatment
Cabozantinib Powder for Cancer Treatment Cabozantinib Description Cabozantinib (marketed under the tradename Cometriq, formerly known as XL184) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM. XL-184 also displays potent activity against Met, Ret, Kit, FLT1, FLT3, FLT4, Tie2, and AXL. XL184...
Product Details


Cabozantinib Powder for Cancer Treatment


Cabozantinib Description


Cabozantinib (marketed under the tradename Cometriq, formerly known as XL184) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM. XL-184 also displays potent activity against Met, Ret, Kit, FLT1, FLT3, FLT4, Tie2, and AXL. XL184 at low concentration(0.1-0.5 μM) is sufficient to induce marked inhibition of constitutive and inducible Met phosphorylation and its resultant downstream signaling in MPNST cells, and inhibit HGF-induced MPNST cell migration and invasion.


Cabozantinib COA

ItemsSpecificationsResults
AppearanceWhite to whitish crystal powderConforms
Loss on dryingNMT 0.5%0.33%
Residue on ignitionNMT 0.1%Conforms
Heavy metalNMT 20ppmConforms
Assay (HPLC)NLT 99.5%99.77%
Related substancesNMT 0.5%0.23%
Single impurityNMT 0.1%0.07%
Conclusion: Complies to the Enterprise standard


How cabozantinib works


Cabozantinib is a cancer growth blocker. It works by blocking particular proteins called protein kinases on cancer cells. The protein kinases encourage the cancer to grow. Cabozantinib blocks a number of these proteins and is called a multi kinase inhibitor. It also stops the cancer cells growing blood vessels, which the cells need to be able to grow.


Cabozantinib may shrink the cancer or stop it growing for a time.

QQ截图20180615141648.jpg

Application


As a pan-tyrosine kinase inhibitor, cabozantinib can affect many biological processes. Cabozantinib inhibits the tubule formation of HMVEC cells with IC50 value of 6.7nM. In B16F10 cells, cabozantinib inhibits HGF-inducedmigration and invasion with IC50 values of 31nM and 9nM, respectively. Moreover, cabozantinib shows anti-proliferation efficacy in a variety of tumors such as SNU-5, Hs746T, MDA-MB-231 and U87MG. It is also reported that the combination of cabozantinib and gefitinib can cause potent inhibition of the gefitinib-resistant HCC827GR6 cell line.


FAQ

xiadanliucheng.jpg

What about the payment,Is it secure?

A:Payment can be TT, West Union, Money Gram and Bitcoin. As a well-known supplier, thousands of buyers pay asmentioned. It is warmly welcome to visit our company, discuss and deal face to face.

 

Have your product quality been approved by Third Party Lab?

A:Yes,All products are strictly tested by our QC,confirmed by QA and approved by third party lab in China,USA,Canada,Germany,UK,Italy,France etc.So you will be assured with Good Quality if you choose us.

 

Do you accept sample order?

A:Yes,we accept small order from 10g,100g and 1kg for your evaluation quality of our goods.

 

Is there any discount?

A:Yes,for larger quantity,we always support with better price.

 

Do you have any reshipment policy?

A:Yes we will reship for totally free if your parcles is seizd by customs unlucky,you dont need to pay any more money

 

Our advantages:
1) Best prices with satisfied quality.
2) Rich experienced in delivering the parcels to you.
3) Enough stock ensure the prompt delivery time.
4) Good after-sales service.
5) Package will be reshipped if sent failed.
6) Specials are possible when the order is big enough.
7)For most products we can provide you a sample, while the cost should undertake by your side.


Hot Tags: cabozantinib powder for cancer treatment, China, suppliers, wholesale, buy
Feedback