Cabozantinib Powder for Cancer Treatment
Cabozantinib (marketed under the tradename Cometriq, formerly known as XL184) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM. XL-184 also displays potent activity against Met, Ret, Kit, FLT1, FLT3, FLT4, Tie2, and AXL. XL184 at low concentration(0.1-0.5 μM) is sufficient to induce marked inhibition of constitutive and inducible Met phosphorylation and its resultant downstream signaling in MPNST cells, and inhibit HGF-induced MPNST cell migration and invasion.
|Appearance||White to whitish crystal powder||Conforms|
|Loss on drying||NMT 0.5%||0.33%|
|Residue on ignition||NMT 0.1%||Conforms|
|Heavy metal||NMT 20ppm||Conforms|
|Assay (HPLC)||NLT 99.5%||99.77%|
|Related substances||NMT 0.5%||0.23%|
|Single impurity||NMT 0.1%||0.07%|
|Conclusion: Complies to the Enterprise standard|
How cabozantinib works
Cabozantinib is a cancer growth blocker. It works by blocking particular proteins called protein kinases on cancer cells. The protein kinases encourage the cancer to grow. Cabozantinib blocks a number of these proteins and is called a multi kinase inhibitor. It also stops the cancer cells growing blood vessels, which the cells need to be able to grow.
Cabozantinib may shrink the cancer or stop it growing for a time.
As a pan-tyrosine kinase inhibitor, cabozantinib can affect many biological processes. Cabozantinib inhibits the tubule formation of HMVEC cells with IC50 value of 6.7nM. In B16F10 cells, cabozantinib inhibits HGF-inducedmigration and invasion with IC50 values of 31nM and 9nM, respectively. Moreover, cabozantinib shows anti-proliferation efficacy in a variety of tumors such as SNU-5, Hs746T, MDA-MB-231 and U87MG. It is also reported that the combination of cabozantinib and gefitinib can cause potent inhibition of the gefitinib-resistant HCC827GR6 cell line.
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A:Yes,All products are strictly tested by our QC,confirmed by QA and approved by third party lab in China,USA,Canada,Germany,UK,Italy,France etc.So you will be assured with Good Quality if you choose us.
Do you accept sample order?
A:Yes,we accept small order from 10g,100g and 1kg for your evaluation quality of our goods.
Is there any discount?
A:Yes,for larger quantity,we always support with better price.
Do you have any reshipment policy?
A:Yes we will reship for totally free if your parcles is seizd by customs unlucky,you dont need to pay any more money
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5) Package will be reshipped if sent failed.
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7)For most products we can provide you a sample, while the cost should undertake by your side.