Lapatinib Ditosylate Cas 388082-77-7

Lapatinib Ditosylate Cas 388082-77-7
Raw Lapatinib Ditosylate Antineoplastic Drug For Breast Cancer CAS 388082-78-8 M onohydrate EGFR Inhibitors GW-572016 Api Pharmaceutical Raw Material Lapatinib ditosylate monohydrate CAS: 388082-78-8 Product Name: Lapatinib ditosylate monohydrate Cas No.: 388082-78-8 MDL No.:MFCD09264195...
Product Details

Raw Lapatinib Ditosylate Antineoplastic Drug For Breast Cancer CAS 388082-78-8 Monohydrate EGFR Inhibitors GW-572016 Api Pharmaceutical Raw Material

Chemical Name

Lapatinib ditosylate monohydrate

CAS

388082-78-8

Purity

99.5%min

MDL

MFCD09264195

Identification

H-NMR; MS

Grade

CP

Molecular Formula

C43H42ClFN4O10S3

Molecular Weight

925.48

Status:

Commercial

Storage

Refrigerated

Lapatinib ditosylate monohydrate CAS: 388082-78-8

Product Name: Lapatinib ditosylate monohydrate
 Cas No.: 388082-78-8
 MDL No.:MFCD09264195
 Molecular Formula:C43H42ClFN4O10S3
 Molecular Weight: 925.48
 Appearance :Yellow crystal powder
 Assay: 99.5%min
 Other Names

Statement:The APls provided by our company are only for scientific research and drug registration,not for any commercial purpose!
 The Cas number of Lapatinib ditosylate monohydrate is 388082-78-8 with the molecular formula of C43H42ClFN4O10S3 and the molecular weight of 925.48.Normally We have some inventory, if there is more demand, our longest delivery time is not more than 4 weeks . We have been in the conventional production of this product . Our process is mature and stable. Welcome to contact us if you have any questions 


 Lapatinib ditosylate Usage And Synthesis  
 Usage anticancer
 Usage binds to a(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors atypical antipsychotic agent


Lapatinib ditosylate Clinical application  
 Lapatinib is used as a treatment for women's breast cancer in treatment-naïve, ER+/EGFR+/HER2+ breast cancer patients and in patients who have HER2-positive advanced breast cancer that has progressed after previous treatment with other chemotherapeutic agents, such as anthracycline, taxane-derived drugs, or trastuzumab (Herceptin).

A 2006 GSK-supported randomized clinical trial on female breast cancer previously being treated with those agents (anthracycline, a taxane and trastuzumab) demonstrated that administrating lapatinib in combination with capecitabine delayed the time of further cancer growth compared to regimens that use capecitabine alone. The study also reported that risk of disease progression was reduced by 51%, and that the combination therapy was not associated with increases in toxic side effects.[10] The outcome of this study resulted in a somewhat complex and rather specific initial indication for lapatinib—use only in combination with capecitabine for HER2-positive breast cancer in women whose cancer have progressed following previous chemotherapy with anthracycline, taxanes and trastuzumab.


Lapatinib ditosylate Adverse effects  
 Like many small molecule tyrosine kinase inhibitors, lapatinib is regarded as well tolerated. The most common side effects reported are diarrhea, fatigue, nausea and rashes. In clinical studies elevated liver enzymes have been reported. QT prolongation has been observed with the use of lapatinib ditosylate but there are no reports of torsades de pointes. Caution is advised in patients with hypokalaemia, hypomagnesaemia, congenital long QT syndrome, or with coadministration of medicines known to cause QT prolongation. In combination with capecitabine, reversible decreased left ventricular function are common


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