Melanotan 1 10mg
Alias: Melanotan-1, Melanotan I, Afamelanotide, Melanotan, CUV1647, EPT1647, NDP-MSH, [Nle4, D-Phe7]伪 -MSH
Appearance: White Lyophilized Powder
Place of Origin: China
Method of Analysis: HPLC
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18C. Upon reconstitution of the peptide it should be stored at 4掳 C between 2-21 days and for future use below -18C.
Melanotan-2 is a synthetic analog of the naturally occurring peptide hormone melanocortin, which stimulates and intensifies skin tan through stimulation of melanin secretion.
Melanotan-2 was developed at the University of Arizona. Researchers claimed that administration of this synthetic peptide into the body could cause sunless tanning. Thus, with the help of this drug it is possible to get beautiful tanning and escape dangerous UV exposure, which can later lead to skin cancer (melanoma). On May 5, 2010 the Italian Medicines Agency (AIFA - Agenzia Italiana del Farmaco) became the first governmental health organization ever to authorize Melanotan-2 as a medicine for therapeutic use to reduce painful photosensitivity.
Melanotan produces its photoprotective effects by triggering a 'signaling cascade' via its activation of the MC1R on melanin-producing cells known as melanocytes.When Melanotan binds to the receptors melanocytes on the epidermal layer of the skin accentuates the start of a series of reactions that results in the production of eumelanin a brown-black pigment. The production of eumelanin instead of pheomelanin by the skin cells increases the pigmentation of the skin, this pigmentation is essential in protecting the skin against harmful ultraviolet radiation
Melanotan 1 (also referred to as Afamelanotide) is a synthetic peptide variant of a peptide hormone, called alpha-Melanocyte stimulating hormone or MSH that is naturally produced in the body and is responsible for stimulating melanogenesis, a peptide process for pigmentation of the skin. Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan-1 sunless skin tanning effects. While Melanotan 2 and PT-141 have been studied at length as a potential remedies for the treatment of sexual dysfunction, Melanotan-1 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.
Both Melanotan-1 and Melanotan 2 are analogs of the peptide hormone alpha-melanocyte stimulating hormone (伪 -MSH) that tend to induce skin tanning. Unlike Melanotan 1, Melanotan 2 has been shown to have aphrodisiac properties, the additional effect of increasing libido. Melanotan-1 is a non selective agonist of the melanocortin receptors (MC1R, MC3-5R). As an analogue of -MSH, its mechanism of action is biomimicry of the natural mammalian tanning process.
MT-1(Melanotan I) Dosage
Start with a dose of 1mg daily for the first two or three days and, if level of side effects permit, look to increase dosage by 0.25mg every day over the next several days until you reach a daily dosage of 2-3mg. This level should be adequate for most users, though some may wish to increase yet further, perhaps as high as 5mg daily in order to achieve a very deep tan. A maintenance phase as described above is then used.