Pain Killer Local Anesthetical Tetracaine HCl/Tetracaine Hydrochloride Powder CAS136-47-0
Tetracaina HCl Descroption
Tetracaina HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tetracaina HCl Applications
Tetracaina (INN, also known as amethocaina; trade name Pontocaina. Ametop and Dicaina) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaina is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaina is an allosteric blocker of channel function. At low concentrations, tetracaina causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaina blocks release completely.
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