Pain Reliever Local Anesthetic Drugs Tetracaine Powder Pain Killer

Pain Killer Powder Local Anesthetic 20-50 Mesh Benzocaine CAS 94-09-7 Description Benzocaine is used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison IVY, poison oak, poison sumac, minor cuts, or scratches. Benzocaine belongs...
Product Details

Pain Reliever Local Anesthetic Drugs Tetracaine Powder Pain Killer CAS94-24-6 

What is the Tetracaine ?

Tetracaine (INN, also known as amethocaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.


In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.


Specification 

Test ItemsSpecificationTest Results
AppearanceFine, white, crystalline, odorless powderconfirm
IdentificationABC in Passconfirm
SolubilityVery soluble in water, soluble in Alcohol;
insoluble in Ether and Benzene
confirm
USP Reference standardsUSP Tetracaine Hydrochloride RS.
USP Endotoxin RS.
confirm
Melting point145~150 degree146.0~147.5 degree
Chromatographic purityIn Passconfirm
Related substanceNot more than the reference solution 0.05%confirm
Heavy metals≤10ppmconfirm
PH4.5-6.55.8
Residue on ignition≤0.10%0.05%
Loss on Drying≤ 0.5%0.19%
Assay98.0 -101.0%100.1%
ConclusionConfirms USP 32



Tetracaine Application


(1) In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.


(2) Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5M(per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) , and 4 or 10 per cent hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.


(3) Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.


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