Tetracaine HCL Cas 136-47-0

Tetracaine HCL Cas 136-47-0
Local Anesthetic Amethocaine Local Anesthesia drugs Tetracaine Powder Tetracaine HCl Cas 136-47-0 Tetracaine HCl Description: Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed...
Product Details

Local Anesthetic Amethocaine Local Anesthesia drugs Tetracaine Powder Tetracaine HCl Cas 136-47-0
  

Product Name

Tetracaine HCl

Alias

Tetracaine hydrochloride,Tetracaine HCL;pontocaine

CAS NO

136-47-0

EINECS

205-248-5

MF

C15H25ClN2O2

MW

300.82

Melting point

149°C

Assay

99%

Grade

Pharmaceutical Grade

Storage

Closed, confined and shading preservation

Usage

Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than Procaine and Lidocaine.


 Tetracaine HCl Description: 
 Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
 Application: 
 Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
 
 In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
 Tetracaine hydrochloride Application:
 Tetracaine hydrochloride is a potent local anesthetic of the ester group.
 It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
 In biomedical research, tetracaine THL is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores.
 Tetracaine hydrochloride is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, Tetracaine hydrochloride blocks release completely.  
 COA

Test Items

Specification

Test Results

Appearance

Fine, white, crystalline, odorless powder

confirm

Identification

ABC in Pass

confirm

Solubility

Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene

confirm

USP Reference standards

USP Tetracaine Hydrochloride RS. USP Endotoxin RS.

confirm

Melting point

145~150 degree

146.0~147.5
degree

Chromatographic purity

In Pass

confirm

Related substance

Not more than the reference solution 0.05%

confirm

Heavy metals

≤10ppm

confirm

PH

4.5-6.5

5.8

Residue on ignition

≤0.10%

0.05%

Loss on Drying

≤ 0.5%

0.19%

Assay

98.0 -101.0%

100.1%

Conclusion

Confirms USP 32


 Usages
 Benzocaine is used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, minor cuts, or scratches.
 Benzocaine belongs to a group of medicines known as topical local anesthetics. It deadens the nerve endings in the skin. This medicine does not cause unconsciousness like general anesthetics do when used for surgery.
 
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