Dapoxetine Hydrochloride CAS No 119356-77-3

Tetracaine Hydrochloride Local Pharmaceutical Anaesthetics White Powder Tetracaine HCL Raw Materials For Pharmaceutical Industry Basic Informations Pharmacodynamics Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor. The physiology of ejaculation primarily depends on serotonin...
Product Details

Tetracaine Hydrochloride Local Pharmaceutical Anaesthetics White Powder Tetracaine HCL Raw Materials For Pharmaceutical Industry

Basic Informations

Product Name:

Dapoxetine hydrochloride

Alias:

Priligy,Dapoxe, Dapoxeti ,Dapoxetinehy, Dapoxetine HCl

CAS No:

119356-77-3

Molecular Formula:

C21H24ClNO

Molecular weight:

341.88

Purity:

98%

Appearance:

White crystalline powder

Grade:

Pharmaceutical Grade

 

Pharmacodynamics 
 Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor. The physiology of ejaculation primarily depends on serotonin and dopamine receptors including 5-HT1a and 5-HT2c. Dapoxetine hydrochloride prevents the reuptake of serotonin transporter. The drug binds with the reuptake transporters of norepinephrine and dopamine and inhibits the reuptake.
 
 
Dapoxetine hydrochloride Dosage 
 For premature ejaculation and erectile dysfunctions (Adults):The recommended adult dose of Dapoxetine hydrochloride is 30 - 60 mg/day. The maximum dose should not exceed 100 mg/day. Take Dapoxetine hydrochloride at least two hours before sexual intercourse to achieve maximum treatment benefits.
 
 
Treat male premature ejaculation and erectile dysfunction.  
 Dapoxetine hydrochloride , marketed as (among and other brands) is the first compound developed specially for the treatment of premature ejaculation (PE) for men between 18-64 years old. Dapoxetine hydrochloride works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, so as to delay consequence ejaculation. As a member of selective serotonin reuptake inhibitor (SSRI) family, 
 
 Dapoxetine hydrochloride, a fast-acting serotonin reuptake transporter inhibitor, is generally prescribed for the treatment and management of premature ejaculation and erectile dysfunction in adult male.Due to the lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as Fluoxetine, Paroxetine, Sertraline, Fluvoxamine, and Citalopram have been used as clinical drugs to treat PE. Waldinger's meta analysis shows that the use of these conventional antidepressants increasing IELT about 2-9 time in comparison of three to eight times when Dapoxetine hydrochloride is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence, an increasing adverse effects such as decreasing sexual libido and causing erectile dysfunction. Dapoxetine hydrochloride, on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug's accumulation in the body, and therefore reducing side effects.


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