Sildenafil Citrate Male Enhancement Powder

Sildenafil Citrate Male Enhancement Powder
Sildenafil Citrate Male Enhancement Powder Quick Detail : Description : Sildenafil citrate, sold under Viagra, Revatio and various other trade names, is a medicament for the treatment of erectile dysfunction and pulmonary hypertension (PAH). It was originally made by Pfizer scientists David...
Product Details

Sildenafil Citrate Male Enhancement Powder 


Quick Detail :


Product name

Sildenafil Citrate

Synonyms

Sildenafil citrate,viagra, Sildenafil

Category

Sex Steroid Hormones

CAS NO.

171599-83-0

Appearance

White Solid

Assay

98%

Molecular formula

C28H38N6O11S

Molecular weight

666.7

Molecular structure

Viagra Sildenafil Citrate Sex Steroid Hormones CAS 171599-83-0 Oral Anti Estrogen Steroid

Delivery time

Within 24 hours upon receipt of payment

Delivery

EMS, DHL, TNT, FedEx, UPS

Usage

An orally active selective type 5 cGMP phosphodiesterase inhibitor
Biological Activity :Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC 50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro.



Description :


Sildenafil citrate, sold under Viagra, Revatio and various other trade names, is a medicament for the treatment of erectile dysfunction and pulmonary hypertension (PAH). It was originally made by Pfizer scientists David Bell, David Brown and Nikolay Twett.

The primary indication of sildenafil is the treatment of erectile dysfunction (unable to maintain a satisfactory erection to complete sexual intercourse). The currently used standard treatment methods include erectile dysfunction, including diabetes, by inhibiting cGMP-specific phosphodiesterase 5 (PDE5) to promote the regulation of penile blood flow in cGMP-degrading enzymes.

In addition to erectile dysfunction, sildenafil citrate can also be effective in rare pulmonary hypertension. It relaxes the arterial wall, leading to reduced pulmonary artery resistance and pressure. Which in turn reduces the workload of the right ventricle of the heart and improves the symptoms of right heart failure. Because PDE5 is mainly distributed in the smooth muscle of the arterial wall of the lung and penis, sildenafil has a selective effect in both regions without causing vasodilatation in other parts of the body. Pfizer submitted an additional registration of sildenafil to the US Food and Drug Administration (FDA), which was approved for use in June 2005. The preparation was named Revatio to avoid confusion with Viagra, 20 mg tablet for white round sildenafil plus bosentan and prostacyclin treatment regimens.



Application :


Sildenafil Citrate treats erectile dys function and works by relaxing muscles and increases blood flow to particular areas of the body (in this case, the penis, specifically). Its effects last up to four hours. The most common side effects of Sildenafil Citrate are headache, facial flushing, and upset stomach. Rarely, blurred vision, or sensitivity to light may briefly occur.


As well as treating impotence, Sildenafil Citrate can also be effective in treating Pulmonary Arterial Hypertension (PAH). Similarly to how it acts to relax muscles of the penis, Sildenafil Citrate relaxes arterial walls; therefore, reducing resistance and pressure in the arteries.



COA :


Items

Specifications

Results

Description

White crystalline powder

White crystalline powder

Solubility

Souble in dimethylformamide,sparingly soluble in acetic acid and slightly soluble in methanol.

Conforms

Identification by A) IR

B)Test for citrates

The absorption maxima in the spectrum obtained with sample corresponds in position relative intensity to those in the spectrum obtained with sildenafil citrate CRS/working standard or with reference spectrum of sildenafil citrate.

To complies as per I.P

Conforms

Melting Range

Between 182 ℃ to 196 ℃

188 ℃-192

Water by KFR

NMT2.0%

1.32%w/w

Citric acid content

28.0 to 34.0% w/w

29.14w/w

Loss on drying at 105 ℃

NMT 1.0% w/w

0.64%w/w

Heavy metals

NMT 20 ppm

Conforms

Sulphated ash

NMT 0.10% w/w

Conforms

Related substance by HPLC

N-Oxide impurity NMT 0.50%

Chloro sulphonyl impurity NMT 0.20%

Any other impurity NMT 0.30%

Total impurities NMT 1.5%

Not detected

Not detected

0.07%

0.20%

Standard

USP32


Recommend Dosage


Viagra (Sildenafil) at 50 mg or 100 mg significantly improved erection quality, treatment satisfaction, anxiety levels, and the sexual experience compared with placebo during DBPC.

Sildenafil 100 mg improved the sexual experience and treatment satisfaction, and reduced feelings of anxiety compared with the 50-mg dose.Viagra (Sildenafil citrate) 50 mg is the recommended starting dose for men with erectile dysfunction (ED); however, most men are later titrated to sildenafil 100 mg for improved efficacy.


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Usage:


As a cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) selective inhibitor, penile smooth muscle relaxation allows rapid erection. Sildenafil is cheap, is the development and production of low-cost classes available kidney yang-like the perfect material for medicine and health products. pharmaceutical material.
Categories: Active Pharmaceutical Ingredients; Miscellaneous Biochemicals; Sildenafil; Erectile Dysfunction.


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