Sildenafil Citrate Male Enhancement Powder
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Sildenafil citrate, sold under Viagra, Revatio and various other trade names, is a medicament for the treatment of erectile dysfunction and pulmonary hypertension (PAH). It was originally made by Pfizer scientists David Bell, David Brown and Nikolay Twett.
The primary indication of sildenafil is the treatment of erectile dysfunction (unable to maintain a satisfactory erection to complete sexual intercourse). The currently used standard treatment methods include erectile dysfunction, including diabetes, by inhibiting cGMP-specific phosphodiesterase 5 (PDE5) to promote the regulation of penile blood flow in cGMP-degrading enzymes.
In addition to erectile dysfunction, sildenafil citrate can also be effective in rare pulmonary hypertension. It relaxes the arterial wall, leading to reduced pulmonary artery resistance and pressure. Which in turn reduces the workload of the right ventricle of the heart and improves the symptoms of right heart failure. Because PDE5 is mainly distributed in the smooth muscle of the arterial wall of the lung and penis, sildenafil has a selective effect in both regions without causing vasodilatation in other parts of the body. Pfizer submitted an additional registration of sildenafil to the US Food and Drug Administration (FDA), which was approved for use in June 2005. The preparation was named Revatio to avoid confusion with Viagra, 20 mg tablet for white round sildenafil plus bosentan and prostacyclin treatment regimens.
Sildenafil Citrate treats erectile dys function and works by relaxing muscles and increases blood flow to particular areas of the body (in this case, the penis, specifically). Its effects last up to four hours. The most common side effects of Sildenafil Citrate are headache, facial flushing, and upset stomach. Rarely, blurred vision, or sensitivity to light may briefly occur.
As well as treating impotence, Sildenafil Citrate can also be effective in treating Pulmonary Arterial Hypertension (PAH). Similarly to how it acts to relax muscles of the penis, Sildenafil Citrate relaxes arterial walls; therefore, reducing resistance and pressure in the arteries.
White crystalline powder
White crystalline powder
Souble in dimethylformamide,sparingly soluble in acetic acid and slightly soluble in methanol.
Between 182 ℃ to 196 ℃
Water by KFR
Citric acid content
28.0 to 34.0% w/w
Loss on drying at 105 ℃
NMT 1.0% w/w
NMT 20 ppm
NMT 0.10% w/w
Related substance by HPLC
Viagra (Sildenafil) at 50 mg or 100 mg significantly improved erection quality, treatment satisfaction, anxiety levels, and the sexual experience compared with placebo during DBPC.
Sildenafil 100 mg improved the sexual experience and treatment satisfaction, and reduced feelings of anxiety compared with the 50-mg dose.Viagra (Sildenafil citrate) 50 mg is the recommended starting dose for men with erectile dysfunction (ED); however, most men are later titrated to sildenafil 100 mg for improved efficacy.
As a cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) selective inhibitor, penile smooth muscle relaxation allows rapid erection. Sildenafil is cheap, is the development and production of low-cost classes available kidney yang-like the perfect material for medicine and health products. pharmaceutical material.
Categories: Active Pharmaceutical Ingredients; Miscellaneous Biochemicals; Sildenafil; Erectile Dysfunction.