Bimatoprost Powder Cas 155206-00-1

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Product Details
  1. Bimatoprost Powder CAS 155206-00-1 for Eye Drops & Hair Growth

  2. Synthetic Prostaglandin Derivatives Bimatoprost CAS 155206-00-1 Pharmaceutical Materials

  3. White Powder 99% Bimatoprost ( TM ) CAS 155206-00-1 for Antiglaucoma

  4. Bimatoprost Powder Injectable Anabolic Steroids CAS 155206-00-1 for Eye Drops & Hair Growth

  5. Medical Bimatoprost Powder , CAS 155206-00-1 Prostamide For Eyelash Hypotrichosis Cure

 

1. Bimatoprost information :

HP1003 EP / USP Standard CAS 155206-00-1 Bimatoprost powder

Bimatoprost

CAS 155206-00-1

Brand: Hyper

MW: 415.57

MSDS: Avaiable

MF : C25H37NO4

Sample: Avaiable

Category:Prostaglandin

Min order: 10grams

Quality standard :EP/USP

Place of Origin:China

Introduction

Bimatoprost is a prostaglandin analog/prodrug used topically (as eye drops) to control the progression of
glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing
the outflow of aqueous fluid from the eyes. It has also been used and prescribed off-label to lengthen eyelashes

Character

White powder, bimatoprost powder

Applications

Pharmaceutical raw materials 


Bimatoprost is a powder, which is very soluble in ethyl alcohol and methyl alcohol and slightly soluble in water. Treating increased pressure in the eye (ocular hypertension) and open-angle glaucoma.
 Its chemical name is (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-N-ethyl-5-heptenamide, and its molecular weight is 415.58. Its molecular formula is C25H37NO4. Its chemical structure is:

Bimatoprost drops are a prostaglandin analog. It works to lower pressure in the eye by increasing fluid drainage from the eye.


2. Bimatoprost ophthalmic solution
 0.03% is indicated to treat hypotrichosis of the eyelashes by increasing their growth including length, thickness and darkness.
 Clinical Pharmacology
 Mechanism of Action
 Bimatoprost is a structural prostaglandin analog. Although the precise mechanism of action is unknown the growth of eyelashes is believed to occur by increasing the percent of hairs in, and the duration of the anagen or growth phase.
 Absorption
 After one drop of bimatoprost ophthalmic solution 0.03% was administered once daily into both eyes (cornea and/or conjunctival sac) of 15 healthy subjects for two weeks, blood concentrations peaked within 10 minutes after dosing and were below the lower limit of detection (0.025 ng/mL) in most subjects within 1.5 hours after dosing. Mean Cmax and AUC0-24hr values were similar on days 7 and 14 at approximately 0.08 ng/mL and 0.09 ng•hr/mL, respectively, indicating that steady state was reached during the first week of ocular dosing. There was no significant systemic drug accumulation over time.
 Distribution
 Bimatoprost is moderately distributed into body tissues with a steady-state volume of distribution of 0.67 L/kg. In human blood, bimatoprost resides mainly in the plasma. Approximately 12% of bimatoprost remains unbound in human plasma.
 Metabolism
 Bimatoprost is the major circulating species in the blood once it reaches the systemic circulation. Bimatoprost then undergoes oxidation, N-deethylation, and glucuronidation to form a diverse variety of metabolites.
 Elimination
 Following an intravenous dose of radiolabeled bimatoprost (3.12 mcg/kg) to six healthy subjects, the maximum blood concentration of unchanged drug was 12.2 ng/mL and decreased rapidly with an elimination half-life of approximately 45 minutes. The total blood clearance of bimatoprost was 1.5 L/hr/kg. Up to 67% of the administered dose was excreted in the urine while 25% of the dose was recovered in the feces.

 

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 1. Mixed container, we can mix different items in one container.
 2. Quality control, before shipment, free sample for test. after shipment, keep sample for 3 years
 3. Prompt shipment with professional documents
 4. Packing as your request, with photo before shipment


 4. Our Adwantage:
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 Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation.
 2. Great quality, purity and favourable.
 Good quality is one of our secret success, each batch of steroid powders have to tested by our QC(quality control) department before they are allowed to sell.
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 We have stock, so we can delivery quickly at the very day when receive the payment.
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 Tell the package update ASAP, and will try best solve when customer encountered various problems.


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