Isotretinoin CAS 4759-48-2

Isotretinoin CAS 4759-48-2
High Potency Active Pharmaceutical Ingredients Isotretinoin 13-Cis Retinoic Pharmaceutical Raw Materials Powder for Acne Treatment Accutane CAS 4759-48-2 Quick details Name: Isotretinoin Alias: 13-cis Vitamin A acid CAS: 4759-48-2 MF: C20H28O2 MW: 300.44 EINECS: 225-296-0 Categories:Antibiotics,...
Product Details

High Potency Active Pharmaceutical Ingredients Isotretinoin  13-Cis Retinoic Pharmaceutical Raw Materials Powder for Acne Treatment Accutane CAS 4759-48-2

Quick details 
Name: Isotretinoin
Alias: 13-cis Vitamin A acid
CAS: 4759-48-2
MF: C20H28O2
MW: 300.44
EINECS: 225-296-0
Categories:Antibiotics, Organicacids, APIs, Pharmaceuticals, Retinoids
Character: yellow or orange crystalline powder
Solubility: practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96%);
Stability: air, light, heat-sensitive, solution stability worse
Loss on drying: ≤0.5%
Content: 99.8%MIN
Heavy Metal: ≤20ppm
Cell culture Test: Pass
Uses: For the treatment of severe acne embolism
Storage conditions: room temperature, damp and dark airtight and dry.

Description
Isotretinoin (INN), also known as 13-cis retinoic acid, is an oral pharmaceutical drug primarily used to treat cystic acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.
Isotretinoin is primarily used as a treatment for severe acne.
Isotretinoin, (also known as 13-cis retinoic acid), is a medication primarily used to treat cystic acne. Rarely, Isotretinoin is also used to prevent certain skin cancers (squamous-cell carcinoma), and can be used in the treatment of brain, pancreatic and other cancers.

Application:
1. Isotretinoin dramatically reduces the size of the skin's oil glands (35%-58%) and even more dramatically reduces the amount of oil these glands produce (around 80%).
2. Isotretinoin,Acne bacteria (P. Acnes) live in skin oil. Since oil is dramatically reduced, so is the amount of acne bacteria in the skin.
3. Isotretinoin slows down how fast the skin produces skin cells inside the pore, which helps pores from becoming clogged in the first place.
4. It has anti-inflammatory properties.


COA:


Items

Specification

Results

Description

Yellow crystalline powder

Orange red crystal

Identification

Complies

Complies

Organic Volatile Impurity

Complies

Complies

Loss on drying

≤0.5%

0.18

residue on ignition

≤0.1%

0.05%

Heavy Metals

<0.002%

<0.002%

Limit of Tretinoin

≤0.1%

0.18%

Assay

98.0~~102.0%

99.5%


Medical Uses

Due to sideeffects and high cost, isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments. Acne treatment usually begins with topical medications (e.g., benzoyl peroxide and adapalene), followed by oral antibiotics and isotretinoin as a last resort.
Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments Acne treatment usually begins with topical retinoids (e.g., tretinoin, adapalene), in combination with topical antibiotics (e.g., clindamycin, erythromycin) or antiseptics (e.g., benzoyl peroxide-containing preparations), followed by oral antibiotics (e.g., doxycycline or minocycline). In women a cyproterone acetate-containing contraceptive pill can be useful if there are no contraindications.
In cases of hormonal acne, such as in women in their 20s and 30s with cyclical acne, often a course of isotretinoin can permanently improve acne obviating the need for lifelong hormonal manipulation.



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