Pramipexole Dihydrochloride

Pramipexole Dihydrochloride
Pharmaceutical ingredient Powder Pramipexole Dihydrochloride Sex Enhancement Raw Medicine Material Steroid Hormone for Parkinson treatment 191217-81-9 Product details Pramipexole CAS: 191217-81-9 MF: C10H21Cl2N3OS MW: 302.26 Appearance: White Powder Purity: 99.5% Grade: Medicine Grade...
Product Details

Pharmaceutical ingredient Powder  Pramipexole Dihydrochloride Sex Enhancement Raw Medicine Material Steroid Hormone for Parkinson treatment 191217-81-9


Product details 

Pramipexole

CAS: 191217-81-9

MF: C10H21Cl2N3OS

MW: 302.26

Appearance: White Powder

Purity: 99.5%

Grade: Medicine Grade


Description

Pramipexole is a dopamine agonist belonging to the same class of drugs as Cabergoline. The primary purpose of this drug is in the treatment of Parkinson's disease. Pramipexole is most commonly found under the brand names Sifrol, Mirapexin and Mirapex, although generics are also available. Mirapex is the most well known brand by Boehringer Ingelheim Pharmaceuticals. Along with treating Parkinson's, Pramipexole is also prescribed for the treatment of restless legs syndrome. The drug has also shown promising signs in the treatment of bipolar depression, although it has never officially held this label.


Application

Pramipexole is a dopamine agonist that directly correlates with the prolactin hormone. As dopamine levels in the body go up, prolactin levels go down. It does this by having a direct effect on the dopamine D3 receptor. Although it also acts on the D2 receptor its affinity for the D3 receptor is seven times greater than any existing dopamine agonist.


The effect of Pramipexole on the D3 receptor has a strong impact on the neurological system, which is why it's used to treat Parkinson's disease and in some cases Alzheimer's disease. Through acting on the D3 receptor, Pramipexole also affects a man's sexual interest and activity. Prolactin is in part directly responsible for a man's refractory period, which refers to the time it takes to recover from sexual activity so that performance can occur again. By lowering prolactin through an increase in dopamine, Pramipexole can directly reduce the refractory period resulting in the ability to perform sexually more frequently.


COA

ITEMS

STANDARDS

RESULTS

Appearance

A white to off white powder

White powder

Identification

A. Meets the requirement

Complies

B. IR: similar to Reference Substance

Complies

Loss on drying

≤0.5%

0.21%

Specific Rotation

+10.0°~+13.0°

+10.8°

Related Substances

Any single impurity ≤0.1%
Total impurity ≤0.8%

0.05%
0.10%

Purity By HPLC R-isomer

≤0.15%

0.10

Residue on ignition

≤0.1%

0.05%

Residual solvents

Isopropyl alcohol ≤5000ppm
Ethyl Acetate ≤5000ppm

150ppm
250ppm

Heavy metals

≤10ppm

Complies

Chlorides

≤0.05%

Complies

Assay

98%~102.0%

99.8%

Conclusion

Analyse according to Factory Standard , Conform

Function

General introduction:Pramipexole dihydrochloride is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease (PD) andrestless legs syndrome (RLS). It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some users of the selective serotonin reuptake inhibitor (SSRI) antidepressants. Pramipexole has shown robust effects on pilot studies in a placebo-controlled proof of concept study in bipolar disorder. It is also being investigated for the treatment of clinical depression and fibromyalgia.

Indications

Parkinson's disease is a neurodegenerative disease affecting the substantia nigra, a component of the basal ganglia. The substantia nigra has a high quantity of dopaminergic neurons, which are nerve cells that release theneurotransmitter known as dopamine. When dopamine is released, it may activate dopamine receptors in the striatum, which is another component of the basal ganglia. When neurons of the substantia nigra deteriorate in Parkinson's disease, the striatum no longer properly receives dopamine signals. As a result, the basal ganglia can no longer regulate body movement effectively and motor function becomes impaired. By acting as an agonist for the D2, D3, and D4 dopamine receptors, pramipexole may directly stimulate the underfunctioning dopamine receptors in the striatum, thereby restoring the dopamine signals needed for proper functioning of the basal ganglia .


Hot steroid powder

Testosterone propionate

Dehydroepiandrosterone acetate

Testosterone

Dehydroepiandrosterone (DHEA)

Testosterone undecanoate

Androsterone

Testosterone enanthate

Androstenediol(HERMAPHRODIOL)

Testosterone cypionate

Androstenedione(4-AD)

Testosterone decanoate

7-keto DHEA

Testosterone acetate

Androstadiendione
(Androsta-1,4-diene-3,17-dione)(ADD)

Testosterone phenylpropionate

Sildenafil citrate (Viagra)

Testosterone isocaproate

Cialis (Tadalafil)

Methyltestosterone(17-methyltestosterone)

vardenafil (Levitra)

Testosterone Sustanon 250

Avanafil

Boldenone Undecylenate(Equipoise)

Acetildenafil (Hongdenafil)

Boldenone Base

Crepis base(HuanYang Alkali)

Boldenone Acetate

JinYang Alkali

Boldenone Cypionate

XinYang Alkali

Boldnone Propionate

Yohimbine hydrochloride

Nandrolone Decanoate(DECA)

Dapoxetine hydrochloride

Nandrolone Undecylate

Dapoxetine

Nandrolone Base

Orlistat

Nandrolone Cypionate

Rimonabant

Nandrolone phenylpropionate

L-carnitine

Nandrolone Propionate

Fenproporex

Trenbolone Acetate(Finaplix)

Androstenedione(4-AD)

Trenbolone Enanthate (parabolan)

Methoxydienone

Trenbolone
(Trienolone, Beta-Trenbolone)

Norandrostenedione (19-nor-4-androstene-
3;Estr-4-ene-3,17-dione)

Trenbolone Hexahydrobenzyl Carbonate

Epiandrosterone

Methyltrienolone(Metribolone)

Methyltestosterone

Drostanolone Propionate(Masteron)

Trendione Trenavar

Drostanolone Enanthate

Stradiene dione-3-keta

Superdrol Powder (methyldrostanolone, Methasterone)

3b-hydroxy-androst-4-ene-17-one

Methenolone Acetate

4-chloro-17a-methyl androst-1,4 diene-3-
17b-dione

Methenolone Enanthate

Androstenedione

Methandrostenolone (Dianabol, methandienone)

Androst-4-ene-3,6,17-trione

Oxymetholone (Anadrol)

6-chloro Testosterone

Stanozolol (Winstrol)

(6b)-6-Bromoandrost-4-ene-3,17-dione

Oxandrolone (Anavar)

17α-Estradiol

Oral turinabol
(4-Chlorodehydromethyltestosterone)

Methyltestosterone (17-Alpha-Methyl
Testosterone)

Tamoxifen Citrate (Nolvadex)

Androstan-17-ol, 2,3-epithio-17-methyl-
, (2a,3a,5a,17b)-

Raloxifene hydrochloride

17A-hydroxyprogesterone

Clomiphene citrate (Clomifene citrate,Clomid)

Coluracetam

Mesterolone (Proviron)

Oxiracetam

Letrozole(Femara)

Aniracetam

Anastrozole (Arimidex)

Piracetam

Exemestane(Aromasin)

Nebracetam

Formestane(Lentaron)

Pramiracetam

Toremifene citrate

Fasoracetam


blob.png

 

blob.png 

 blob.png

blob.png

 blob.png


Hot Tags: pramipexole dihydrochloride, China, suppliers, wholesale, buy
Feedback