High Quality Local Anesthetic Agents Powder Pregabalin (Lyrica) Pharmaceutical Raw Material for Anesthsia CAS:148553-50-8
Product Name : Prilocaine
Synonyms : 2-(propylamino)-o-propionotoluidid;2-(Propylamino)-o-propionotoluidide;2-Methyl-alpha-propylaminopropionanilide;alpha-n-Propyl-amino-2-methylpropionanilide;alpha-n-propylamino-2-methylpropionanilide;Astra 1512;Astra 1515;astra1512
CAS : 721-50-6
MF : C13H20N2O
MW : 220.31
EINECS : 211-957-0
Product Categories : Active Pharmaceutical Ingredients
Chemical properties : acicular crystallization. The melting point of 37-38 degrees, 159-162 degrees (0.133kPa) of boiling point, refractive index (nD20) 1.5299. The hydrochloride ([1786-81-8]) is a white crystalline powder. Temperature 167-168 degrees. Soluble in water and ethanol, slightly soluble in chloroform. Sour bitter taste, no smell.
1. Propitocaine hydrochloride is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils L Fgren. In its injectable form, it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used forintravenous regional anaesthesia.
2. In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue.
3.Local anesthetic is a substance that causes loss of sensation only to the area to which it is applied without affecting consciousness. Most local anesthetics structures have amino-ester or an amino-amide group which are linked to hydrophilic (secondary or 4.tertiary amine) and to hydrophobic group (aromatics) on the other side.
3. Local anesthetics, long duration, lower toxicity, chemicals that are also small Suitable for epidural anesthesia, block anesthesia and infiltration anesthesia, etc.
A white to off white powder
A. Meets the requirement
B. IR: similar to Reference Substance
Loss on drying
Any single impurity ≤0.1%
Purity By HPLC R-isomer
Residue on ignition
Isopropyl alcohol ≤5000ppm
Analyse according to Factory Standard , Conform
|Product name||Prilocaine hydrochloride|
|CAS No.||1786-81-8||Packing||25KG/Cardboard drum|
|Date of manufacturing||11th, March, 2017||Shelf life||10th, March, 2019|
|Description||White crystalline powder||Complies|
|Solubility||Freely soluble in water and in alcohol,slightly soluble in chloroform, very slightly soluble in acetone, practically insoluble in ether||Complies|
|Identification||Should be positive response||Complies|
|Loss on drying||≤ 0.3%||0.13%|
|Residue on ignition||≤0.1%||0.03%|
|Residual solvents||Should comply with the standard||Complies|
|Assay||99.0% ~101.0%(on dried basis)||99.46%|