Pregabalin CAS:148553-50-8

Pregabalin CAS:148553-50-8
High Quality Local Anesthetic Agents Powder Pregabalin (Lyrica) Pharmaceutical Raw Material for Anesthsia CAS:148553-50-8 Product details Product Name : Prilocaine Synonyms :...
Product Details

High Quality Local Anesthetic Agents Powder Pregabalin (Lyrica) Pharmaceutical Raw Material for Anesthsia CAS:148553-50-8


Product details

Product Name : Prilocaine
Synonyms : 2-(propylamino)-o-propionotoluidid;2-(Propylamino)-o-propionotoluidide;2-Methyl-alpha-propylaminopropionanilide;alpha-n-Propyl-amino-2-methylpropionanilide;alpha-n-propylamino-2-methylpropionanilide;Astra 1512;Astra 1515;astra1512
CAS : 721-50-6
MF : C13H20N2O
MW : 220.31
EINECS : 211-957-0
Product Categories : Active Pharmaceutical Ingredients
Chemical properties : acicular crystallization. The melting point of 37-38 degrees, 159-162 degrees (0.133kPa) of boiling point, refractive index (nD20) 1.5299. The hydrochloride ([1786-81-8]) is a white crystalline powder. Temperature 167-168 degrees. Soluble in water and ethanol, slightly soluble in chloroform. Sour bitter taste, no smell.


Description

1. Propitocaine hydrochloride is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils L Fgren. In its injectable form, it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used forintravenous regional anaesthesia.

2. In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue.

3.Local anesthetic is a substance that causes loss of sensation only to the area to which it is applied without affecting consciousness. Most local anesthetics structures have amino-ester or an amino-amide group which are linked to hydrophilic (secondary or 4.tertiary amine) and to hydrophobic group (aromatics) on the other side.

3. Local anesthetics, long duration, lower toxicity, chemicals that are also small Suitable for epidural anesthesia, block anesthesia and infiltration anesthesia, etc.

 

Specification:

ITEMS

STANDARDS

RESULTS

Appearance

A white to off white powder

White powder

Identification

A. Meets the requirement

Complies

B. IR: similar to Reference Substance

Complies

Loss on drying

≤0.5%

0.21%

Specific Rotation

+10.0°~+13.0°

+10.8°

Related Substances

Any single impurity ≤0.1%
Total impurity ≤0.8%

0.05%
0.10%

Purity By HPLC R-isomer

≤0.15%

0.10

Residue on ignition

≤0.1%

0.05%

Residual solvents

Isopropyl alcohol ≤5000ppm
Ethyl Acetate ≤5000ppm

150ppm
250ppm

Heavy metals

≤10ppm

Complies

Chlorides

≤0.05%

Complies

Assay

98%~102.0%

99.8%

Conclusion

Analyse according to Factory Standard , Conform

 

COA:

Product namePrilocaine hydrochloride
CAS No.1786-81-8Packing25KG/Cardboard drum
Date of manufacturing11th, March, 2017Shelf life10th, March, 2019
Standard adoptedUSP36
ItemsSpecificationResults
DescriptionWhite crystalline powderComplies
SolubilityFreely soluble in water and in alcohol,slightly soluble in chloroform, very slightly soluble in acetone, practically insoluble in etherComplies
IdentificationShould be positive responseComplies
Melting Point166~169ºC166~168ºC
Loss on drying≤ 0.3%0.13%
Residue on ignition≤0.1%0.03%
Heavy metals≤0.002%<0.002%
Residual solventsShould comply with the standardComplies
Assay99.0% ~101.0%(on dried basis)99.46%
ConclusionQualified

 Uses of Tranexamic Acid

1.Hemostatic, significant effect on traumatic bleeding, preoperative prophylactic medication can decrease operation hemorrhage.

2. The chemical structure of tranexamic acid and lysine, competitive inhibition of plasminogen to fibrin adsorption, to prevent their activation, protect the fiber protein was not degraded by the enzyme and dissolved, ultimately achieve hemostasis effect.
3. All applicable in the treatment of acute or chronic, localized or systemic primary fibrinolysis hyperfunction caused by bleeding, such as obstetric hemorrhage, renal hemorrhage, hypertrophy of the prostate, hemophilia hemorrhage, pulmonary tuberculosis hemoptysis, bleeding in the stomach, liver, lung, spleen and other organs of hemorrhage after operation
4. The clinical effect of tranexamic acid on insect bites, eczema and dermatitis, simple purpura, chronic urticaria, artificial sex urticaria, rash and drug poisoning effect, also have certain effects on erythroderma, scleroderma, SLE, erythema multiforme, herpes zoster and alopecia areata, curative effect of hereditary angioedema is also good.


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