Bimatoprost Prostamide Raw Material Synthetic Prostaglandin Derivatives Bimatoprost Pharmaceutical Materials for Glaucoma Treatment CAS 155206-00-1
English Name: Bimatoprost
Other Names : Prostamide
CAS Number 155206-00-1
Molecular Formula C25H37NO4
Molecular Weight 415.27
Appearance: crystalline solid
Bimatoprost (marketed in the U.S., Canada and Europe by Allergan, under the trade name) is aprostaglandin analog/prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluidfrom the eyes. In December 2008, the indication to lengthen eyelashes was approved by the U.S. Food and Drug Administration (FDA); the cosmetic formulation of bimatoprost is sold as Latisse In 2008-2011, at least three case series suggested that bimatoprost has the ability to reduce adipose (fat) tissue.
Functions and Usages
Bimatoprost is used in the treatment of open angle glaucoma and ocular hypertension in adult patients, either alone or in combination with beta blockers (usually timolol).
Studies have shown that bimatoprost is more effective than timolol in lowering intraocular pressure (IOP) and is as effective as intraocular pressure-lowering prostaglandin analog latanoprost and travoprost.
It has been noted that in patients using octoprosts such as travoprost and latanoprost, the diameter, density and length of the eyelashes have increased. A study published in May 2010 found that bimatoprost in gel suspension significantly increases eyelash length when applied to the bottom of upper eyelashes. Allergan started a clinical trial investigating the use of bimatoprost as a cosmetic drug. In 2008, the FDA Skin and Ophthalmic Advisory Committee voted to approve the use of bimatoprost cosmetics to blacken and elongate eyelashes. Medical terms are used to treat hair thinning disorders. However, the approval of the FDA is purely cosmetic (see prostaglandin F receptor # clinical significance)
|CAS No.||155206-00-1||Outer Packing||1g/foil bag|
|Production date||2016/11/6||Shelf life||2018/11/5|
|Standard adopted||Enterprise standard|
|Appearance||White to almost white powder||White powder|
|Identification||HPLC retention time of sample complies with that of known sample||Complies|
|Specific rotation||[a ]D20 : +33.0° 〜+37.00 (C=1.0,CH3CN)||+35.4°|
|15R-Bimatoprost:||NMT 0.30%||Not detected|
|Bimatoprost free acid:||NMT 0.10%||Not detected|
|5,6-trans-Bimatoprost:||NMT 0.50% Any||0.15%|
|other single impurity:||NMT 0.10%||0.03%|
|Total other impurities:||NMT 0.50%||0.06%|
|Ter-Butylmethyl ether:||NMT 5000ppm||lppm|
|Ethanol: NMT 5000ppm n-Hexane:||NMT||36ppm 3 ppm|
|290ppm Ethyl acetate:||NMT 5000ppm||Not detected|
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