|Application||For lab research|
|Storage||Keep in cool and dry place|
|Package||aluminium alloy bag or according to requirement|
|Place of origin||China|
|Type of shipping||EMS, TNT, FEDEX, DHL,ect|
|Payment terms||T/T,Western Union, Money Gram|
4-Fluoromethylphenidate (also known as 4-FMPH and 4F-MPH) is a stimulant drug that acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate
4-Fluoromethylphenidate was studied further along with other analogues of (±)-threo-methylphenidate (TMP) to assess their potential as anti-cocaine medications. 4F-MPH was reported as having an ED50 mg/kg of 0.26 (0.18–0.36) and a relative potency of 3.33 to Methylphenidate.
Another study found that in the threo-isomers of methylphenidate, the meta- and para-substituted compounds with electron-withdrawing substituents tended to have increased binding potency.
Usage and Application
Beginning in the 1960s, it was used to treat children with ADHD orADD, known at the time as hyperactivity or minimal brain dysfunction(MBD). Today Methylphenidate is the most commonly prescribedmedication to treat ADHD around the world.Production andprescription of Methylphenidate rose significantly in the 1990s,especially in the United States, as the ADHD diagnosis came to bebetter understood and more generally accepted within the medical andmental health communities.
Attention deficit hyperactivity disorder Methylphenidate is approved by the FDA for the treatment ofattention-deficit hyperactivity disorderThe addition of behaviouralmodification therapy (e.g. CBT) has additional benefits on treatmentoutcomeThere is a lack of evidence of the effectiveness in the longterm of beneficial effects ofMethylphenidate with regard tolearning and academic performance.A meta analysis of the literatureconcluded that Methylphenidate quickly and effectively reduces thesigns and symptoms of ADHD in children under the age of 18 in theshort term but found that this conclusion may be biased due to thehigh number of low quality clinical trials in the literature. Therehave been no placebo controlled trials investigating the long termeffectiveness of Methylphenidate beyond 4 weeks thus the long termeffectiveness of Methylphenidate has not been scientificallydemonstrated. Serious concerns of publication bias regarding the useof Methylphenidate for ADHD has also been noted.A diagnosis of ADHDmust be confirmed and the benefits and risks and proper use ofstimulants as well as alternative treatments should be discussedwith the parent before stimulants are prescribed.The dosage used canvary quite significantly from individual child to individual childwith some children responding to quite low doses whereas otherchildren require the higher dose range. The dose therefore should betitrated to an optimal level which achieves therapeutic benefit andminimal side effectsTherapy with Methylphenidate should not beindefinite. Weaning off periods to assess symptoms are recommended.
Has demonstrated value as part of a comprehensive treatment programfor ADHD. Safety and efficacy in children <6 years of age notestablished. Use with caution in patients with bipolar disorder,diabetes mellitus, cardiovascular disease, hyperthyroidism, seizuredisorders, insomnia, porphyria, or hypertension. Use caution inpatients with history of ethanol or drug abuse. May exacerbatesymptoms of behavior and thought disorder in psychotic patients.
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