Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species. Estradiol or oestradiol (American or British English usages), derives from estra-, Gk. οστρο? (oistros, literally meaning "verve or inspiration") and -diol, a chemical name and suffix indicating that this form of steroid and sex hormone is a type of alcohol bearing two hydroxyl groups.
Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone). One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations.Action of aromatase on this dione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.
Functional primary care: 1. Used for uterine cervix, especially for postmenopausal syndromes and senile vaginitis. Can be used as an adjuvant for intermediate and induced abortion. Used for enlarged prostate, prostate cancer, etc. The function of leukocyte is rapidly elevated, which takes effect from 1 to 3 days after taking the drug, but the effect is shorter. Loss of white blood cells due to chemotherapy or radiation therapy. 5. Can reduce the permeability of blood vessels and brittle, and can be used for a variety of the treatment of bleeding, menorrhagia, tonsil or after hysterectomy, have rapid hemostatic effect.
1.Estriol is a Safe and Effective Hormone for Menopausal Women with Hot Flashes and Vaginal Dryness
2.Estriol Protects Against Breast and Uterine Cancers
3.Estriol as a Replacement Estrogen in Breast Cancer Survivors
4.Estriol Prevents Vaginal Atrophy and Urinary Tract Infections
5.Estriol Does Not Cause Blood Clots
6.Estriol Protects the Skin From Aging
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