Estrogen Powder Top Quality Anti Keoxifene Raloxifene Hydrochloride CAS 82640-04-8 Supplier
light yellow crystalline powder
Raloxifene will be like tamoxifen as effective, and less adverse effects
Raloxifene hydrochloride Description:
Raloxifene hydrochloride is a second-generation Selective Estrogen Receptor Modulator (SERM) of the benzothiophene family. This drug is similar in effect to tamoxifen, exhibiting estrogen receptor antagonist (blocking) properties in some tissues while acting as an estrogen receptor agonist (activator) in others.
The main point of variation between these two agents is their tissue selectivity. While raloxifene hydrochloride is a strong anti-estrogen in breast and uterine tissues, it appears to be estrogenic in bone. This allows it to protect bone density, mimicking the beneficial effects of endogenous estradiol. This is quite different from tamoxifen, which is anti-estrogenic in both breast and bone.
In a role that was novel for an anti-estrogen, raloxifene hydrochloride was approved by the FDA for the prevention and treatment of osteoporosis in post-menopausal women. It is also being investigated for several other potential uses, including the treatment and prevention of cardiovascular disease, breast cancer, gynecomastia, prostate cancer, acromegaly, and uterine cancer.
Raloxifene hydrochloride Mechanism of Action:
Evista (raloxifene hydrochloride) is an estrogen agonist/antagonist, referred to as a selective estrogen receptor modulator (SERM) and belongs to the benzothiophene class of compounds. The biological actions of raloxifene are largely mediated through binding to estrogen receptors.
This binding results in activation of estrogenic pathways in some tissues (agonism) and and the blockade of estrogenic pathways in other tissues (antagonism). The agonistic or antagonistic activity of raloxiffene depends on the extent of recruitment of coactivators and corepressors to estrogen receptor (ER) target gene promotors.
Raloxifene appears to act as an estrogen agonist in bone. It decreases bone resorption and bone turnover, increases bone mineral density and decreases fracture incidence.
How to order products?
1. Please tell me the details about products you need, which include product name and quantity.
2. We quote, offer payment terms and shipping methods.
3. You agree and choose one of payment terms which you convinent.
4. We arrange packing and shipment after received money.
5. We offer good after-sale service after you receive goods.
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC ,
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
Q3. How to cooperate with us?
You can contact us for cooperation through the website contact information, or contact with the salesmen in our company. We will connect you about the specific detail via email.
Q4: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.
Q5: Is there any discount?
A: Yes, for larger quantity, we always support with better price.
Q6:What payment you can accept ?
A:we can accept T/T , Moneygram , Western Union, Paypal.
Q7How long does it take to the goods arrived ?
A:It is Depending on your location,
For small order, please expect 7-10 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 10-15 days by Air, 20-35 days by Sea.
Q8 Do you have any reshipment policy ?
we have good after-sale service and re-shipment policy if the parcel lose
Our long association with our clients has brought great benefits
We always take the upmost care in the packaging of our products
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible will seize a small number of packages.
In this circumstance we promise reship free to establish long term relationship
Q9 How to proceed order?
Let me konw the items,quantity and the destination contury wihch help me to give you a right price
Please let me know the items you are looking for, quantity and the destination country.After you confirm all details of order, pay money 100% in advance and give us Shipping address.We arrange the shipment at first time after receive payment and offer after-sales service after you receive parcel.