Raloxifene Hydrochloride CAS No 82640-04-8

Estrogen Powder Top Quality Anti Keoxifene Raloxifene Hydrochloride CAS 82640-04-8 Supplier Basic Info Raloxifene hydrochloride Description: Raloxifene hydrochloride is a second-generation Selective Estrogen Receptor Modulator (SERM) of the benzothiophene family. This drug is similar in effect...
Product Details

Estrogen Powder Top Quality Anti Keoxifene Raloxifene  Hydrochloride CAS 82640-04-8 Supplier

Basic  Info

Product name

Raloxifene hydrochloride

Synonyms

Keoxifene

CAS No.

82640-04-8

M.F.

C28H29NO4S

M.W.

475.5992

Appearance

light yellow crystalline powder

USES

Raloxifene will be like tamoxifen as effective, and less adverse effects


 Raloxifene  hydrochloride Description: 
 
Raloxifene hydrochloride is a second-generation  Selective Estrogen Receptor Modulator (SERM) of the benzothiophene family. This  drug is similar in effect to tamoxifen, exhibiting estrogen receptor antagonist  (blocking) properties in some tissues while acting as an estrogen receptor  agonist (activator) in others.
  
 The main point of variation between these two agents is their tissue  selectivity. While raloxifene hydrochloride is a strong anti-estrogen in  breast and uterine tissues, it appears to be estrogenic in bone. This allows it  to protect bone density, mimicking the beneficial effects of endogenous  estradiol. This is quite different from tamoxifen, which is anti-estrogenic in  both breast and bone.
  
 In a role that was novel for an anti-estrogen, raloxifene hydrochloride  was approved by the FDA for the prevention and treatment of osteoporosis in  post-menopausal women. It is also being investigated for several other  potential uses, including the treatment and prevention of cardiovascular  disease, breast cancer, gynecomastia, prostate cancer, acromegaly, and uterine  cancer.
  
 Raloxifene hydrochloride Mechanism of Action: 
 Evista (raloxifene hydrochloride) is an estrogen agonist/antagonist, referred  to as a selective estrogen receptor modulator (SERM) and belongs to the  benzothiophene class of compounds. The biological actions of raloxifene are  largely mediated through binding to estrogen receptors.
  
 This binding results in activation of estrogenic pathways in some tissues  (agonism) and and the blockade of estrogenic pathways in other tissues  (antagonism). The agonistic or antagonistic activity of raloxiffene depends on  the extent of recruitment of coactivators and corepressors to estrogen receptor  (ER) target gene promotors.
  
Raloxifene appears to act as an estrogen agonist in bone. It decreases bone  resorption and bone turnover, increases bone mineral density and decreases  fracture incidence.

How  to order products?
 1. Please tell me the details about products you need, which include product  name and quantity.
 2. We quote, offer payment terms and shipping methods.
 3. You agree and choose one of payment terms which you convinent.
 4. We arrange packing and shipment after received money.
 5. We offer good after-sale service after you receive goods.

FAQ
 Q1: Have your Product Quality been Approved by  Third Party Lab?
 A: Yes, All products are strictly tested by our QC, confirmed by QA and approved  by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So  you will be assured with Good Quality if you choose us.   
 Q2:How do you treat quality complaint?

 A:First of all, our QC department will do strict examination of our export  products by HPLC, UV, GC , 
 TLC and so on in order to reduce the quality problem to near zero. If there is  a real quality problem ,caused by us, we will send you free goods for  replacement or refund your loss.  
 Q3. How to cooperate with us?
 You can contact us for cooperation through the website contact information, or  contact with the salesmen in our company. We will connect you about the  specific detail via email.  
 Q4: Do you Accept Sample Order?
 A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation  quality of our goods. 
 Q5: Is there any discount?
 A: Yes, for larger quantity, we always support with better price.  
 Q6:What payment you can accept ?
 A:we can accept T/T  , Moneygram , Western Union, Paypal. 
 Q7How long does it take to the goods arrived ?
 A:It is Depending on your location,
   For small order, please expect 7-10 days by  DHL,UPS,TNT, FEDEX, EMS.
 For mass order, please allow 10-15 days by Air, 20-35 days by Sea. 
 Q8 Do  you  have  any  reshipment  policy  ?  
 we have good after-sale service and re-shipment policy if the  parcel  lose
 Our long association with  our clients has brought great benefits
 We always take the upmost care in the packaging of our products 
 our clients will confirm this as even they struggle to find them without help  at times.
 But in spite of our best efforts it is still possible  will seize  a small number of packages.
 In this circumstance we promise reship free  to  establish  long term relationship  
 Q9 How to proceed order?
 Let me konw the items,quantity and the destination contury wihch help me to  give you a right price
 Please let me know the items you are looking for, quantity and the destination  country.After you confirm all details of order, pay money 100% in advance and  give us Shipping address.We arrange the shipment at first time after receive  payment and offer after-sales service after you receive parcel.


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