CAS 148553-50-8 Local Anesthesia Drugs Pregabalin Fit Antiepileptic

CAS 148553-50-8 Local Anesthesia Drugs Pregabalin Fit Antiepileptic
Specification Descroption : Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults.It has also been found effective for generalized anxiety disorder,it was designed as a more potent...
Product Details

Specification

PregabalinCAS 148553-50-8Brand: SUNSANTA
MW:159.23MSDS: Avaiable
MF : C8H17NO2Sample: Avaiable
Category: APIMin order: 10grams
Quality standard: Enterperise standardPlace of Origin:China
UsageS-Enantiomer of Pregabalin. A GABA analogue used as an anticonvulsant. Anxiolytic analgesic used to treat peripheral neuropathic pain and fibromyalgia.
Applications

Pharmaceutical raw materials

Descroption :

Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults.It has also been found effective for generalized anxiety disorder,it was designed as a more potent successor to gabapentin
Pregabalin also known as β-isobutyl-γ-Aminobutyric acid (β-isobutyl-GABA) and sold under the brand name Lyrica is a medication primarily used for epilepsy, neuropathic pain, and fibromyalgia.Its use for epilepsy is as an add-on therapy for partial seizures with or without secondary generalization in adults.It is also considered useful for generalized anxiety disorder.

Pregabalin is a derivative of the naturally occurring inhibitory neurotransmitter γ-Aminobutyric acid (GABA) and classified as a depressant by the Drug Enforcement Agency.It is a neurotransmitter modulator that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating properties. Pregabalin is a potent gabapentinoid and a close structural analogue of GABOB (β-hydroxy-GABA), baclofen (β-(4-chlorophenyl)-GABA), and phenibut (β-phenyl-GABA)
Pregabalin is used to relieve neuropathic pain (pain from damaged nerves) that can occur in your arms, hands, fingers, legs, feet, or toes if you have diabetes or in the area of your rash if you have had shingles (a painful rash that occurs after infection with herpes zoster). It is also used to treat fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep). Pregabalin is used with other medications to treat certain types of seizures in people with epilepsy. Pregabalin is in a class of medications called anticonvulsants. It works by decreasing the number of pain signals that are sent out by damaged nerves in the body.

Pregabalin Usage And Synthesis


Antiepileptic drus and therapeutic drugs for neuropathic pain Pregabalin is a new
antiepileptic drug, having a γ-amino butyric acid structure on its molecular structure, which
has anticonvulsant effects, and is successfully developed by the company Pfizer for the
treatment of peripheral neuropathic pain, or adjuvant treatment of partial seizures.
In December 2008, the US Food and Drug Administration (FDA) approved pregabalin (trade name
"Lyrica") for the treatment of diabetic peripheral neuropathic pain (DPN) and postherpetic
neuralgia (PHN)which are Both the most common neuropathic pains.
Neuropathic pain is one of the most difficult chronic pain syndromes to treat , dull pain,
burning, tingling as the main feature, there are a lot of incentives of neuralgia, diabetes,
infections (such as herpes zoster), cancer and AIDS, etc. can cause neurological pain, in
Europe about 3% of the population suffer from neuralgia torture.
The above information is edited by the chemicalbook of Tian Ye.

Uses S-Enantiomer of Pregabalin.

A GABA analogue used as an anticonvulsant. Anxiolytic
analgesic used to treat peripheral neuropathic pain and fibromyalgia.
Uses Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy
for partial seizures, and in generalized anxiety disorder. It was designed as a more potent
successor to gabapentin.



Pregabalin COA:


ITEMSSTANDARDSRESULTS
AppearanceA white to off white powderWhite powder
IdentificationA. Meets the requirementComplies
B. IR: similar to Reference SubstanceComplies
Loss on drying≤0.5%0.21%
Specific Rotation+10.0°~+13.0°+10.8°
Related SubstancesAny single impurity ≤0.1%
Total impurity ≤0.8%
0.05%
0.10%
Purity By HPLC R-isomer≤0.15%0.10
Residue on ignition≤0.1%0.05%
Residual solventsIsopropyl alcohol ≤5000ppm
Ethyl Acetate ≤5000ppm
150ppm
250ppm
Heavy metals≤10ppmComplies
Chlorides≤0.05%Complies
Assay98%~102.0%99.8%
ConclusionAnalyse according to Factory Standard , Conform


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