Clobetasol Propionate For Anti-inflammatory

Clobetasol Propionate For Anti-inflammatory
Clobetasol Propionate For Anti-inflammatory Quick details Description Clobetasol propionate is classed as a very potent topical corticosteroid. Topical corticosteroids are also referred to as topical steroids. Topical steroids are used in addition to moisturisers (emollients) for treating...
Product Details

Clobetasol Propionate For Anti-inflammatory



Quick details 


Manufacturer

Zhuhai Wumei Technology Co., Ltd

Standard adopted

USP38

Items of analysis

Specification

Results

Description

White or almost white crystalline powder

Almost white crystalline powder

Solubility

Practically insoluble in water, slightly soluble in benzene and diethyl ether, sparingly soluble ethanol, soluble in acetone and in dimethyl sulfoxide, in chloroform, in methanol and in dioxane

Complies

Identification (IR)

Complies with the Standard

Complies

Specific Rotation

+98°~+104°

+100.4°

Melting point

About 196ºC

195.0ºC~197.0ºC

Loss on drying

Max. 2.0%

0.20%

Residue on ignition

Max. 0.1%

0.04%

Heavy Metals

Max. 20ppm

Complies

Single impurity

N. M. T 1.0%

0.16%

Sum impurity

N. M. T 2.5%

0.46%

Organic volatile impurities

Meet the ICH requirement

Complies

Assay(HPLC, basisondrying)

98.5%~102.0%

99.9%

THF

Not more than 720ppm

Complies

Methanol

Not more than 3000ppm

Complies

DMF

Not more than 880ppm

Complies

Pyridine

Not more than 200ppm

Complies

Dichloromethane

Not more than 600ppm

Complies

Ethanol

Not more than 5000ppm

Complies

Acetone

Not more than 5000ppm




Description


Clobetasol propionate is classed as a very potent topical corticosteroid. Topical corticosteroids are also referred to as topical steroids. Topical steroids are used in addition to moisturisers (emollients) for treating inflammatory skin conditions such as eczema anddermatitis. A topical steroid is used when patches of eczema or dermatitis flare up. Clobetasol propionate relieves the symptoms of a flare-up by reducing inflammation, itching and redness. It is not a cure for the condition, but it will help to relieve the symptoms.


Specialist skin doctors may on occasion prescribe a short course of clobetasol propionate for the treatment of psoriasis, although it is not generally recommended for this skin condition. Clobetasol propionate is not recommended for use in children, although again, it may be prescribed for a child by a specialist doctor under certain circumstances.


Clobetasol propionate is available as a number of different preparations. It is likely you will be prescribed a cream if the affected areas of your skin are moist or weeping, or an ointment if your skin is dry. It is also available as a shampoo and as an application for the scalp.


There is also a preparation available which contains two antibacterial agents called neomycin and nystatin. You may be prescribed this preparation for short-term use if your skin has become infected. It is typically used twice a day for one week only.



Application


1. Clobetasol Propionate used for the treatment of various skin disorders including eczema, herpes labialis, psoriasis, and lichen sclerosus.

2. it used to treat several auto-immune diseases including alopecia areata, vitiligo, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma).

3. it is used as first-line treatment for both acute and chronic GVHD of the skin.

4. Clobetasol propionate is used cosmetically by dark-skinned women for skin whitening,



Clobetasol Propionate Uses


Clobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis,[3] psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases including alopecia areata, vitiligo, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). It is used as first-line treatment for both acute and chronic GVHD of the skin.


Clobetasol proprionate is used cosmetically by dark-skinned women for skin whitening, although this use is controversial. The U.S. Food and Drug Administration has not approved it for that purpose, and sales without a prescription are illegal in the U.S. Nonetheless, it is often sold in U.S. retail beauty supply stores and on the internet. It is also sold internationally, and does not require a prescription in some countries.

Whitening creams with clobetasol proprionate, such as Hyprogel, can make skin thin and easily bruised, with visible capillaries, and acne. It can also lead to hypertension, elevated blood sugar, suppression of the body’s natural steroids, and stretch marks, which may be permanent.


Clobetasol propionate is with mercury and hydroquinone "amongst the most toxic and most used agents in lightening products." Many products sold illegally have higher concentrations of clobetasol propionate than is permitted for prescription drugs.


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