Estradiol For Female

Estradiol For Female
Estradiol for Female Quick Detail Description Estradiol cypionate , or estradiol cipionate, is a synthetic ester, specifically the 3-cyclopentylpropanoyl ester, of the natural estrogen, estradiol. It was first introduced in 1952 by Upjohn in the United States, and has been in widespread use...
Product Details


Estradiol for Female



Quick Detail


Product nameEstradiol
Other nameBeta-Estradiol; B-estradiol; 17ß -Estradiol; β-estradiol; 1,3,5-estratriene-3,17beta-diol; 17beta-estradiol; 3,17beta-dihydroxy-1,3,5(10)-estratriene; dihydrofolliculin;
CAS50-28-2
Einecs200-023-8
MFC18H24O2
MW272.382

Molecular Structure

Purity99%
AppearanceWhite crystalline powder
UsageEstradiol is essential for the development and maintenance of female reproductive tissues


Description


Estradiol cypionate , or estradiol cipionate, is a synthetic ester, specifically the 3-cyclopentylpropanoyl ester, of the natural estrogen, estradiol. It was first introduced in 1952 by Upjohn in the United States, and has been in widespread use since. Estradiol cypionate is absorbed more slowly than estradiol itself, and for that reason, it can be administered less often.Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate was found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate were found to last for 4-5 days and 7-8 days, respectively.



Estradiol Applications:


1. Sexual development


The development of secondary sex characteristics in women is driven by estrogens, to be specific, estradiol. These changes are initiated at the time of puberty, most are enhanced during the reproductive years, and become less pronounced with declining estradiol support after the menopause. Thus, estradiol produces breast development, and is responsible for changes in the body shape, affecting bones, joints, and fat deposition. Fat structure and skin composition are modified by estradiol.


2. Female reproduction


In the female, estradiol acts as a growth hormone for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium, and the lining of the fallopian tubes. Estradiol enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary.

During the menstrual cycle, estradiol produced by the growing follicle triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to the luteinizing hormone surge, inducing ovulation. In the luteal phase, estradiol, in conjunction with progesterone, prepares the endometrium for implantation.


3. Male reproduction


The effect of estradiol (and estrogens in general) upon male reproduction is complex. Estradiol is produced by action of aromatase mainly in the Leydig cells of the mammalian testis, but also by some germ cells and the Sertoli cells of immature mammals.

Estradiol functions (in vitro) to prevent apoptosis of male sperm cells. While some studies in the early 1990s claimed a connection between globally declining sperm counts and estrogen exposure in the environment, later studies found no such connection, nor evidence of a general decline in sperm counts. Suppression of estradiol production in a subpopulation of subfertile men may improve the semen analysis.

Males with certain sex chromosome genetic conditions, such as Klinefelter's syndrome, will have a higher level of estradiol.


4. Bone


Estradiol has a profound effect on bone. Individuals without it (or other estrogens) will become tall and eunuchoid, as epiphyseal closure is delayed or may not take place. Bone structure is affected also, resulting in early osteopenia and osteoporosis.

Also, women past menopause experience an accelerated loss of bone mass due to a relative estrogen deficiency.


5. Brain


Estrogens can be produced in the brain from steroid precursors. As antioxidants, they have been found to have neuroprotective function.

The positive and negative feedback loops of the menstrual cycle involve ovarian estradiol as the link to the hypothalamic-pituitary system to regulate gonadotropins.


6. Gynecological cancers


Estradiol has been tied to the development and progression of cancers such as breast cancer, ovarian cancer and endometrial cancer.

Estradiol has complex effects on the liver. In high amounts, it can lead to cholestasis. Estradiol affects the production of multiple proteins, including lipoproteins, binding proteins, and proteins responsible for blood clotting.

Estrogen affects certain blood vessels. Improvement in arterial blood flow has been demonstrated in coronary arteries.

Several benign gynecologic conditions are dependent on estrogen, such as endometriosis, leiomyomata uteri, and uterine bleeding.



COA:

TEST ITEMSSPECIFICATIONRESULTS
DescriptionWhite or Almost White Crystalline Powderwhite powder
IdentificationA.B.Positive
Assay97.0~102.0%99.3%
Specific Rotation+101°~+105°+102.6°
Loss On Drying1.0%max0.27%
Melting Point153~157°C153.0~155.0°C
Organic Volatile Impuritiesmeets the requirement.Conforms
Related Substancesmeets the requirement.Conforms
Residual Solventsmeets the requirement.Conforms
Particle Size100% ≤ 20 micronsConforms
ConclusionThe specification conform with USP30 standard



FAQ

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What about the payment,Is it secure?

A:Payment can be TT, West Union, Money Gram. As a well-known supplier, thousands of buyers pay asmentioned. It is warmly welcome to visit our company, discuss and deal face to face.

 

Have your product quality been approved by Third Party Lab?

A:Yes,All products are strictly tested by our QC,confirmed by QA and approved by third party lab in China,USA,Canada,Germany,UK,Italy,France etc.So you will be assured with Good Quality if you choose us.

 

Do you accept sample order?

A:Yes,we accept small order from 10g,100g and 1kg for your evaluation quality of our goods.

 

Is there any discount?

A:Yes,for larger quantity,we always support with better price.

 

Do you have any reshipment policy?

A:Yes we will reship for totally free if your parcles is seizd by customs unlucky,you dont need to pay any more money

 


Our advantages


1) Best prices with satisfied quality.
2) Rich experienced in delivering the parcels to you.
3) Enough stock ensure the prompt delivery time.
4) Good after-sales service.
5) Package will be reshipped if sent failed.
6) Specials are possible when the order is big enough.
7)For most products we can provide you a sample, while the cost should undertake by your side.



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