Letrazole Steroid Powders Femara Hormone For Anti-Breast Cancer

Letrazole Steroid Powders Femara Hormone For Anti-Breast Cancer
Letrazole Steroid Powders Femara Hormone for Anti-Breast Cancer Product details Name: Letrazole Other name: Femara Appearance: White or light yellow crystal CAS :112809-51-5 MF:C17H11N5 MW:285.31 Assay:99%min Melting point:181-183 潞 C Usage: Used as API in Treatment of breast disease Description...
Product Details

Letrazole Steroid Powders Femara Hormone for Anti-Breast Cancer

 

Product details

Name: Letrazole

Other name: Femara

Appearance: White or light yellow crystal

CAS :112809-51-5

MF:C17H11N5

MW:285.31

Assay:99%min

Melting point:181-183C

Usage: Used as API in Treatment of breast disease

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Description

Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally sensitive breast cancer

Estrogens are produced by the conversion of androgens through the activity of the enzyme aromatase. Letrozole blocks estrogen production in this way through a competitive and reversible binding to the heme of its cytochrome P450 unit. The action is specific and letrozole does not reduce the production of minerals or corticosteroids. On the contrary, the antiestrogenic action of tamoxifen, the main medical therapy prior to the arrival of aromatase inhibitors, is because it interferes with the estrogen receptor, rather than inhibiting estrogen production.

 

Applications

Letrozole has been used for ovarian stimulation by fertility doctors since 2001 because it has fewer side-effects than clomiphene (Clomid) and less chance of multiple gestation. A Canadian study presented at the American Society of Reproductive Medicine 2005 Conference suggested that letrozole may increase the risk of birth defects.[citation needed] A more detailed ovulation induction follow-up study found that letrozole, compared with a control group of clomiphene, had significantly lower congenital malformations and chromosomal abnormalities at an overall rate of 2.4% (1.2% major malformations) compared with clomiphene 4.8% (3.0% major malformations). Despite this, India banned the usage of letrozole in 2011, citing potential risks to infants.In 2012, an Indian parliamentary committee said that the drug controller office colluded with letrozole's makers to approve the drug for infertility in India and also stated that letrozole's use for infertility was illegal worldwide; however, such off-label uses are legal in many countries such as the US and UK.

 

The anti-estrogen action of letrozole has been shown to be useful in pretreatment for termination of pregnancy, in combination with misoprostol. It can be used in place of mifepristone, which is expensive and unavailable in many countries.

Letrozole is sometimes used as a treatment for gynecomastia, although it is probably most effective at this if caught in an early stage (such as in users of anabolic steroids).

Letrozole has also been shown to delay the fusing of the growth plates in mice.When used in combination with growth hormone, letrozole has been shown effective in one adolescent boy with a short stature.


COA

Appearance

White or off-white crystaline powder

White
Crystalline powder

Solubility

Soluble in Chloroform;
Soluble in ethanol when heated

Conform

ldentification

(1)Maximum absorption in wavelength
of 240 nm Minimum absorption in 
wavelength of 215 nm

Conform

(2)Infrared spectrum should be
in accordance
the dominant peak of contrast

In accordance with the dominant peak
of contrast

Melting points

182ºC-184ºC

182ºC

Related substances

≤0.5%

0.3%

Single impurity

≤0.3%

0.2%

Loss on drying

≤1.0%

0.8%

[Assay]C17H11N5
(On anhydrous basis)

≥98.0%

99.2%


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