Tetracaine Basic Details What is the Tetracaine ? Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal...
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Tetracaine is a prescription medication used to prevent pain and induce anesthesia.
What is the Tetracaine ?
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
(1) In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
(2) Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5M(per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) , and 4 or 10 per cent hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
(3) Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tetracaine is given as an injection through a needle placed into an area of your middle or lower back near your spine. You will receive this injection in a hospital setting.
Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving tetracaine injection.
Spinal numbing medicines can have long-lasting effects on certain body processes such as sexual function, bowel or bladder control, and movement or feeling in your legs or feet. Talk with your doctor about these effects.
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
Since tetracaine is given as needed before a surgery or other medical procedure, you are not likely to be on a dosing schedule.
To make sure you can safely receive tetracaine, tell your doctor if you have any of these other conditions:
high blood pressure; heart disease, heart rhythm disorder; any type of infection; hereditary angioedema or a history of allergic reactions; or a disease or medical condition that affects your brain or spinal cord. It is not known whether tetracaine will harm an unborn baby. Unless you are receiving this medicine during labor and delivery, tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
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