Prohormone Powder 4-Androstenedione
4-Androstenedione is the common precursor of male and female sex hormones. Some 4-Androstenedione is also secreted into the plasma, and may be converted in peripheral tissues to testosterone and estrogens.
4-Androstenedione can be synthesized in one of two ways. The primary pathway involves conversion of 17-hydroxypregnenolone to dehydroepiandrosterone by way of 17,20-lyase, with subsequent conversion of dehydroepiandrosterone to 4-Androstenedione via the enzyme 3-β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to 4-androstenedione directly by way of 17,20-lyase. Thus, 17,20-lyase is required for the synthesis of 4-androstenedione, whether immediately or one step removed.
The production of adrenal 4-Androstenedione is governed by ACTH, whereas production of gonadal 4-Androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total 4-androstenedione(about 3 mg/day). After menopause, 4-androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the ovary. Nevertheless, 4-androstenedione is the principal steroid produced by the postmenopausal ovary.
How does it work?
Due to its secretion from a number of different glands and its often rapid conversion to other hormones, the control of 4-Androstenediones within the body is very complex. However, two key parts of the brain (the hypothalamus and pituitary gland) are known to be important in the control of 4-Androstenediones secretion from the testes, ovaries and adrenal cortex. The release of 4-Androstenediones by the adrenal cortex is thought to be related to the pituitary gland's secretion of a specialised hormone, adrenocorticotropic hormone. Precisely how adrenocorticotropic hormone and other hormones control the adrenal gland's production of 4-Androstenediones is, however, unclear. The testes and ovaries are stimulated to release 4-Androstenediones by luteinising hormone and follicle stimulating hormone. These are released from the anterior pituitary gland in response to a hormone signal from the hypothalamus.
Because androstenedione can be converted to estrogenic steroids, people taking this supplement may have estrogenic side-effects.
4-Androstenedione has been shown to increase serum testosterone levels over an eight-hour period in men when taken as a single oral dose of 300 mg per day, but a dose of 100 mg had no significant effect on serum testosterone. However, serum levels of estradiol increased following both the 100 mg and 300 mg doses. The study also reported that the serum level of estrogens and testosterone produced varied widely between individuals.
In child development, higher levels of androstenedione in boys have been associated with higher levels of acting out behaviors.
4- Androstenedione can be used as pharmaceutical material, steroid hormone and anabolin.
4- Androstenedione can be used for treatment of anorchia replacement therapy.
4- Androstenedione can be used to increase the number of muscle.
Delivery and shipping:
1. We will ship within 48h after payment.
2. We will ship by UPS,EMS,DHL, TNT,ect . We will choose the best courier depend on Different countries, and find the safe way to deliver the goods for you.
3. Like Russia, Australia, Canada, customs is very strict, but we can ensure 95% delivery.we have our special ways only for you.
4. As usual you can get the goods with in 4-10days. If the goods were lost or not received for other reasons, we'll resend for free.
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Do you accept sample order?
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Is there any discount?
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Do you have any reshipment policy?
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