High Purity Anabolic Steroids Hormone Aicar Acadesine Sarm Powder Diseases Treatment with High Quality
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Apperance: White or off-white powder.
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases
AICAR is an activator that permeates the cell membrane AMP-activatedproteinkinase (AMPK). AMPK is a key protein in metabolic regulation. When the energy supply is insufficient, the ratio of AMP/ATP increases, and AMPK will be activated to inhibit the synthesis of metabolism. AICAR activates AMPK, but does not affect the level of ATP, ADP, and AMP. At the cellular or animal level, AICAR can promote glucose uptake of skeletal muscle non-insulin dependence by activating AMPK. An AICAR induced glucose intake of skeletal muscle cannot be blocked by a PI3K inhibitor.
Related substance (HPLC)
Total impurity ≤0.5% Max single impurity ≤0.1%
100% pass 80 mesh
Loss on Drying Residue on Ignition
Total Plate Count
Yeast & Mold
AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research.
Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes.
Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).
The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase
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